Bone Mineral Density in Children with Congenital Adrenal Hyperplasia

Background: C Treatment in all forms of CAH includes lifelong replacement steroids. Steroids have an impact on bone health multiple ways and are known to cause osteoporosis when given high doses or for a longer duration. Objective: To evaluate mineral density (BMD), using dual-energy X-ray absorptiometry (DEXA) scan children with taking long-term steroids presenting the pediatric endocrinology ward National Institute Child Health, (NICH) Karachi, Pakistan. Materials Methods: This cross-sectional study was performed at Department Pediatric Endocrinology, Karachi from October 2021 July 2022. A total 47 diagnosed cases more than 5 years were enrolled. Assessment BMD done DEXA scan. Lumbar spine Z-score modified height age z-score. The dose duration calculated. Results: Out patients, low observed 8 (17.02%) patients. Individuals had significantly higher median duration, (p=0.017), (p=0.003), alkaline phosphate level (p=0.036),) but value (p=0.009) z score (p<0.001) normal individuals. Although appropriate chronologic moderate negative significant correlation between (rho=-0.319, p=0.029), z-score steroid treatment (rho=-0.364, p=0.012), (rho=-0.466, p=0.001), (rho=-0.378, p=0.009). Conclusion: Low 17% Moreover, these individuals average hydrocortisone.